All nonsteroidal anti-inflammatory agents (NSAIDs), those that inhibit cyclo-oxygenase-2 (COX)-2 or the conventional, nonselective agents, gamble the risk of myocardial infarction (MI), according to the results of a population-based, matched case-control rumination conducted in Finland.
“Our results do not device the view that COX-selectivity alone determines the cardiovascular adverse effects of NSAIDs, at least concerning MI,” lead police officer Dr.
Arja Helin-Salmivaara and colleagues note in their information, published in the July supplying of the European Disposition Account book.
Accumulating data on the cardiovascular risks associated with COX-2 inhibitors have called into interrogative sentence the preventative of nonselective NSAIDs, they note.
Previous randomized studies were underpowered to evaluate rare events, such as MI, and observational studies have yielded inconsistent results.
The investigators evaluated data for 33,309 patients with a starting time MI entered into the Finnish Infirmary Outpouring Cash register between 2000 and 2003.
These subjects were compared with 138,949 spirit subjects matched by age, sex, and medical building catchment area.
The NSAIDs used included: conventional NSAIDs (diclofenac, ibuprofen, indomethacin, ketoprofen, naproxen, mefenamic acid, piroxicam, tenoxicam, tolfenamic acid, aceclofen, tiaprofenic acid); semiselective NSAIDs (etodolac, nabumetone, nimesulide and meloxicam); and COX-2 inhibitors (rofecoxib, celecoxib, valdecoxib and etoricoxib).
Dr.
Helin-Salmivaara from the Establishment of Turku, in Helsinki, and colleagues determined the adjusted odds quantitative relation associated with line use of each drug, after adjusting for comorbidities, hormone therapy and other drugs that reduce MI risk.
This is a part of article NSAIDs Slightly Increase Risk of MI Taken from "Generic Arcoxia (Etoricoxib)" Information Blog
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