Sunday, January 06, 2008

FDA brief shows CV risk with etoricoxib. Part 2


In footing of cardiovascular contraceptive device,
etoricoxib appears to be “worse than each comparator.” For CV-related
deaths, there appears to be an indulgence of cases due to etoricoxib
compared with medicament, although the pic to medicine is limited, the
limited review comments.
However, the data related to naproxen clearly show an surfeit of CV
death rate related to etoricoxib (and this is consistent with what has
been seen in other studies comparing naproxen with rofecoxib [Vioxx, Merck & Co], which was withdrawn from the mart because of an increased cardiovascular risk.)

Work-clothing, the periodical of pooled
cardiovascular/thromboembolic events is similar in all groups, the
author says, but when cardiac events are specifically examined, there
is an alteration with etoricoxib compared with medication, naproxen,
and diclofenac. “This is especially true for myocardial infarctions” in
the EDGE contemplation, which compared etoricoxib with
diclofenac in 7000 patients.
Also, an psychoanalysis of new ischemic fondness disease reveals an
alteration in events related to etoricoxib compared with vesper,
naproxen, or nonnaproxen NSAIDs.

The
increased CV risk appears to be dose related—the risk of CV events in
patients taking etoricoxib 60 mg is similar to vesper, and the
increased rate of CV events is due for the most part to the 90-mg dose.
In acquisition, there appears to be, work-clothes, an addition in
hypertension-related adverse events and in
congestive-heart-failure-related events in the etoricoxib-treated
patients.



This is a part of article FDA brief shows CV risk with etoricoxib. Part 2 Taken from "Generic Arcoxia (Etoricoxib)" Information Blog

No comments: