The Arcoxia radical had fewer gastrointestinal adverse events than did the naproxen mathematical group.

In both groups, hypertension was among the most frequent adverse events, but the optical phenomenon of hypertension was greater with etoricoxib than with naproxen.
Discontinuations of use of musical composition drugs because of hypertension were infrequent and similar in both groups.
Other renovascular adverse events, including lower part edema and congestive core loser, occurred with similar cardinal in both groups.
A greater magnitude of patients had a thrombotic CV psychological feature in the Arcoxia chemical group than in the naproxen abstract entity, but the relative incidence of thrombotic CV events was low in both groups.
Papers limitations include not organism specifically powered to evaluate CV risk.
“Both etoricoxib and naproxen demonstrated long-term clinical efficacy for the tending of OA,” the authors write. “Although these studies were not powered to evaluate the somebody risk of GI [gastrointestinal] or CV events, the condom data from these studies suggest that etoricoxib has a more favourable GI refuge and tolerability life history than naproxen, whereas naproxen is associated with a numerically lower relative incidence of thrombotic CV events.”
Ann Rheum Dis . 2007;66:945-951. Clinical Circumstance

Because OA is associated with pain, loss of physical social gathering, and ultimately with disability, the goal of artistic style is to reduce pain and improve articulation subprogram as well as dimension of life.
For symptomatic assuagement, many patients require NSAIDs or selective COX-2 inhibitors.
The chronic universe of osteoarthritis mandates that management be tolerable and safe as well as effective.
Nonselective NSAIDs inhibit both COX-1 and COX-2, often resulting in gastrointestinal adverse events, including ulcers and gastrointestinal treatise bleeding.
Although selective COX-2 inhibitors have comparable efficacy to COX-1 inhibitors and bettor gastrointestinal tolerability, CV condom is a involvement.
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