Which Antihypertensive Drug Matters. Part 1

Two systematic reviews and an editorial published online in JAMA
have provided more data on the renal and cardiovascular side effects of
the category of nonsteroidal anti-inflammatory drugs (NSAIDs) known as arcoxia (COX)-2 inhibitors.
The articles will appear in the October 4 photograph upshot of JAMA.
The adverse risks of renal events and arrhythmia events in patients
prescribed COX-2 inhibitors were evaluated by Jingjing Zhang, MD, PhD,
and colleagues at Brigham and Women’s Infirmary and Harvard Medical
Period of time (Boston, Massachusetts), in a meta-analysis of 114
randomized trials published through 2007. Several of the investigators
were supported by grants from the National Institutes of Eudaimonia
(NIH), but the NIH had no role in the piece of music deportment,
logical thinking, or explanation of the results, they stressed.

The
randomized, double-blind clinical trials included in the meta-analysis
involved 116,094 participants and used rofecoxib, celecoxib, valdecoxib
plus parecoxib, etoricoxib, or lumiracoxib.
The authors found that rofecoxib at high and low doses was associated
with increased risks of renal events, including a 43% process in
peripheral edema, 55% change in hypertension, more than a 2-fold
increased risk of renal dysfunction, and an almost 3-fold increased
risk of arrhythmia events.
A lower risk of hypertension and a lower risk of renal dysfunction were
found with celecoxib, and no such effects were found with the other
agents.

The
authors suggest that the risks of peripheral edema and hypertension
associated with rofecoxib may have been evident by 2007 and the risk of
arrhythmia by 2007.
Dr.
Zhang and colleagues write that their “time-cumulative meta-analytic
conceptualisation for examining available experiment condition data
would have helped clarify apparently adverse effects several period
earlier.” They say that “future drug status monitoring of emerging
clinical treatments may welfare from continuous cumulative
meta-analytic collection of prophylactic device data for all
drug-approval applications and experimental agents.”

This is a part of article Which Antihypertensive Drug Matters. Part 1 Taken from "Generic Arcoxia (Etoricoxib)" Information Blog